Recombinant Human TTK protein, MYC/DDK-tagged

• Cat.No.: TTK-12H
• Product Overview: Recombinant Human TTK fused with MYC/DDKtag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Myc&DDK
• Description: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 96.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TTK TTK protein kinase [ Homo sapiens ]
• Official Symbol: TTK
• Synonyms: TTK; TTK protein kinase; dual specificity protein kinase TTK; cancer/testis antigen 96; CT96; MPS1L1; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; ESK; PYT; MPS1; FLJ38280
• Gene ID: 7272
• mRNA Refseq: NM_003318
• Protein Refseq: NP_003309
• MIM: 604092
• UniProt ID: P33981
• Chromosome Location: 6q13-q21
• Pathway: Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem
• Function: ATP binding; binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity