TTK
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Official Full Name
TTK protein kinase -
Overview
TTK (Mps1, PYT) is a cell cycle regulated dual specificity kinase present in rapidly proliferating tissues and cell lines. TTK localizes to kinetochores and centromeres and is an essential component of the mitotic spindle checkpoint as well as centrosome -
Synonyms
TTK;TTK protein kinase;dual specificity protein kinase TTK;cancer/testis antigen 96;CT96;MPS1L1;monopolar spindle 1-like 1;phosphotyrosine picked threonine kinase;phosphotyrosine picked threonine-protein kinase;ESK;PYT;MPS1;FLJ38280
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Sf9 Cells
- HEK293
- Mammalian Cells
- Insect Cells
- Sf21 Cells
- His
- GST
- DDK&Myc
- Non
- Flag&GST
- Flag
Involved Pathway
TTK involved in several pathways and played different roles in them. We selected most pathways TTK participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | YWHAG1,TINF2,NEDD1,CCND1,DYNC1I2,RB1,NEK9,TMPO,CDC7,CCNE1 |
Protein Function
TTK has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TTK itself. We selected most functions TTK had, and list some proteins which have the same functions with TTK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | MINK1,OBSCN,IRAK4,TSSK6,CLK1,CDK5,ARAF,MAP3K2,ALPK1,RPS6KAL |
| protein tyrosine kinase activity | DYRK1B,SRC,FYN,BTK,MAP2K3,Aatk,AXL,KITB,EPHB4B,WEE1 |
| protein serine/threonine/tyrosine kinase activity | CLK3,DSTYK,AURKB,RPS6KA2,AURKA,DYRK1A,TNK2,ACVR2B,CLK4,RPS6KB1 |
| ATP binding | CDK14,CDK1,MAP3K10,MARK2,RIPK4,RBM4.3,SMC3,SMCHD1,DICER1,OASL1 |
| protein binding | ELAVL2,KCTD1,CPNE1,SUMO2,THSD4,MRPL1,PIP,FRMD4B,ADRB1,LRRC29 |
Interacting Protein
TTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTK here. Most of them are supplied by our site. Hope this information will be useful for your research of TTK.
N/A;TACC2;CDCA8;LRRK2;TUBB;Ttk;RPS6KA1;MAPK6;IBTK;NAA50;KIF2A;UTRN;RPL7A;SNW1;ESPL1;GEMIN5;HERC5
Resources
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References
- Aruga, A; Takeshita, N; et al. Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. CLINICAL CANCER RESEARCH 19:2224-2231(2013).
- Wang, LN; Su, WJ; et al. CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. BIOMATERIALS 33:5107-5114(2012).
