Recombinant Human TSPO protein, His & GST-tagged

• Cat.No.: TSPO-1696H
• Product Overview: Recombinant Human TSPO aa. (Met1~Glu169 (Accession # P30536)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: Met1~Glu169
• Description: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 48.8kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 9.4
• Publications:
  Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies (2019)

Gene Information

• Gene Name: TSPO translocator protein [ Homo sapiens (human) ]
• Official Symbol: TSPO
• Synonyms: TSPO; translocator protein; DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18; benzodiazepine peripheral binding site; mitochondrial benzodiazepine receptor; peripheral-type benzodiazepine receptor
• Gene ID: 706
• mRNA Refseq: NM_000714.5
• Protein Refseq: NP_000705.2
• UniProt ID: P30536