Recombinant Human TSPO, MYC/DDK-tagged

• Cat.No.: TSPO-51H
• Product Overview: Recombinant Human TSPO fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.

Specification

• Cat. No.: TSPO-51H
• Description: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
• Source: HEK293 Cells
• Molecular Mass: 18.6 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Storage buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
• Concentration: > 50 ug/ml as determined by BCA
• Storage: Store at -80oC. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
• OfficialSymbol: TSPO
• Tag: Myc&DDK

Gene Information

• Gene Name: TSPO translocator protein (18kDa) [ Homo sapiens ]
• Synonyms: TSPO; translocator protein (18kDa); benzodiazapine receptor (peripheral) , BZRP; translocator protein; DBI; IBP; MBR; mDRC; PBR; peripheral type benzodiazepine receptor/recognition site; pk18; PKBS; mitochondrial benzodiazepine receptor; benzodiazepine peripheral binding site; peripheral-type benzodiazepine receptor; PBS; BPBS; BZRP; PTBR
• Gene ID: 706
• mRNA Refseq: NM_000714
• Protein Refseq: NP_000705
• MIM: 109610
• UniProt ID: P30536
• Chromosome Location: 22q13.31
• Pathway: HTLV-I infection; Neuroactive ligand-receptor interaction
• Function: androgen binding; benzodiazepine receptor activity; cholesterol binding

Reviews

01/28/2023

Prolonged transportation will not affect the stability of the product.

07/11/2021

The price of this one is very reasonable, and the quality is very good, I am very satisfied.

02/13/2020

It has high solubility and can be dissolved quickly.

Q&As

How does TSPO affect neuroprotection?

TSPO has an impact on neuroprotection by modulating mitochondrial function to affect the survival and death of nerve cells. Specific mechanisms include inhibition of apoptosis and alleviation of oxidative stress.

What are the challenges and prospects of current research on TSPO?

At present, the research on TSPO faces some challenges, such as the difference in the expression of TSPO in various tissues, the functional changes of TSPO in different disease states, and the interaction between TSPO and other molecules. However, with the continuous advancement of technology and the in-depth understanding of the functions of TSPO, it is expected that there will be greater breakthroughs in drug design and treatment strategies for TSPO in the future.

How is TSPO involved in the synthesis and transport of cholesterol?

This protein regulates the permeability of mitochondrial membranes to cholesterol by binding to cholesterol transporters, thereby affecting cholesterol synthesis and trafficking.

Is TSPO associated with a variety of diseases,

Since TSPO is associated with a variety of diseases,it may be a therapeutic target for a variety of diseases, such as neurodegenerative diseases, cancer, and mental disorders. Some progress has been made in the design and development of drugs for TSPO.

How to detect the expression and function of TSPO?

Commonly used TSPO detection methods include immunohistochemistry, western blotting, flow cytometry, etc. In addition, TSPO ligands can also be used for binding experiments or functional experiments to study their biological functions.

What circumstances does the expression level of TSPO change?

The expression level of TSPO changes in a variety of physiological and pathological conditions, such as hypoxia, ischemia, inflammation, aging, etc. These changes affect the function of the mitochondria, which affects the survival and death of cells.