Recombinant Human TRIM24 Protein, Flag-tagged

• Cat.No.: TRIM24-335H
• Product Overview: Full length Recombinant Human TRIM24 (Tripartite Motif Containing 24) Protein is produced in SF9 Insect Cells and is fused with a Flag tag at the N-terminal.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Description: TRIM24 (UniProt/Swiss-Prot entry O15164) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. It acts as a a transcriptional coactivator through it’s interaction with several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors, and coactivators thereby modulating the transcription of target genes. TRIM24 is thought to associate with chromatin. This association depends on histone H3 modifications with the highest affinity for histone H3 that is both unmodified at 'Lys-4' and acetylated at 'Lys-23'. Defects in TRIM24 cause thyroid papillary carcinoma.
• Form: 20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
• Purity: Purified using FPLC, >95% purity as determined by SDS-PAGE.
• Notes: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
• Stability: Guaranteed stable for 2 years from date of receipt when stored properly.
• Storage: Store at -80 centigrade.
• Concentration: 0.5 µg/µl
• Full Length: Full L.

Gene Information

• Gene Name: TRIM24 tripartite motif containing 24 [ Homo sapiens ]
• Official Symbol: TRIM24
• Synonyms: TRIM24; tripartite motif containing 24; hTIF1; RNF82; TIF1A; Tif1a; TIF1-alpha; PTC6; TF1A; TIF1; TIF1ALPHA
• Gene ID: 8805
• mRNA Refseq: NM_003852
• Protein Refseq: NP_003843
• MIM: 603406
• UniProt ID: O15164