Recombinant Human TPM3

• Cat.No.: TPM3-30684TH
• Product Overview: Recombinant fragment of Human Tropomyosin 3 with N terminal proprietary tag, 41kDa.

Specification

• Description: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
• Molecular Weight: 41.000kDa
• Source: E. coli
• Form: Lyophilised:Add 200ul of distilled water.
• Storage buffer: pH: 6.80Constituents:1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the tropomyosin family.
• Tag: Non

Gene Information

• Gene Name: TPM3 tropomyosin 3 [ Homo sapiens ]
• Official Symbol: TPM3
• Synonyms: TPM3; tropomyosin 3; NEM1; tropomyosin alpha-3 chain; TRK
• Gene ID: 7170
• mRNA Refseq: NM_001043351
• Protein Refseq: NP_001036816
• MIM: 191030
• Uniprot ID: P06753
• Chromosome Location: 1q21.2
• Pathway: Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem
• Function: actin binding; molecular_function