Recombinant Human TPM1 Protein, His-tagged

• Cat.No.: TPM1-165H
• Product Overview: Recombinant Human TPM1(Met1-Met284), transcript variant 5, fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 20mM Tris, 1mM DTT, 100mM NaCl, 20% Glycerol, pH 8.0.
• Molecular Mass: 35 kDa
• Protein length: Met1-Met284
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TPM1 tropomyosin 1 (alpha) [ Homo sapiens ]
• Official Symbol: TPM1
• Synonyms: TPM1; tropomyosin 1 (alpha); C15orf13, cardiomyopathy, hypertrophic 3 , chromosome 15 open reading frame 13 , CMH3; tropomyosin alpha-1 chain; alpha-tropomyosin; sarcomeric tropomyosin kappa; cardiomyopathy, hypertrophic 3; tropomyosin 1 (alpha) isoform 1; tropomyosin 1 (alpha) isoform 2; tropomyosin 1 (alpha) isoform 3; tropomyosin 1 (alpha) isoform 4; tropomyosin 1 (alpha) isoform 5; tropomyosin 1 (alpha) isoform 6; tropomyosin 1 (alpha) isoform 7; CMH3; TMSA; CMD1Y; C15orf13; HTM-alpha
• Gene ID: 7168
• mRNA Refseq: NM_000366
• Protein Refseq: NP_000357
• MIM: 191010
• UniProt ID: P09493