Recombinant Human TP73

• Cat.No.: TP73-30454TH
• Product Overview: Recombinant full length Human p73 Gamma with N-terminal proprietary tag; MWt 85 kDa.

Specification

• Description: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
• Protein length: 476 amino acids
• Molecular Weight: 85.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Tag: Non

Gene Information

• Gene Name: TP73 tumor protein p73 [ Homo sapiens ]
• Official Symbol: TP73
• Synonyms: TP73; tumor protein p73; P73
• Gene ID: 7161
• mRNA Refseq: NM_001126240
• Protein Refseq: NP_001119712
• MIM: 601990
• Uniprot ID: O15350
• Chromosome Location: 1p36.3
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Measles, organism-specific biosystem
• Function: chromatin binding; damaged DNA binding; double-stranded DNA binding; metal ion binding; p53 binding