Recombinant Human TP63 Protein, His-tagged

• Cat.No.: TP63-468H
• Product Overview: Recombinant Human TP63 Protein (Pro540-Glu680) with N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Pro540-Glu680
• Description: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 19.9 kDa
  Accurate Molecular Mass: 18 kDa
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: TP63 tumor protein p63 [ Homo sapiens (human) ]
• Official Symbol: TP63
• Synonyms: TP63; tumor protein p63; TP53CP, TP53L, TP73L, tumor protein p53 competing protein, tumor protein p53 like, tumor protein p73 like; tumor protein 63; EEC3; KET; NBP; OFC8; p51; p53CP; p63; p73H; p73L; SHFM4; CUSP; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta; AIS; LMS; RHS; p40; TP53L; TP73L; TP53CP; B(p51A); B(p51B)
• Gene ID: 8626
• mRNA Refseq: NM_001114978
• Protein Refseq: NP_001108450
• MIM: 603273
• UniProt ID: Q9H3D4