Recombinant Human TNNT2, His-tagged

• Cat.No.: TNNT2-26212TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-285 of human Cardiac Troponin T fused to His tag at N-terminus; 305 amino acids, 36.4 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-285 a.a.
• Description: The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.
• Conjugation: HIS
• Tissue specificity: Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK
• Sequence Similarities: Belongs to the troponin T family.

Gene Information

• Gene Name: TNNT2 troponin T type 2 (cardiac) [ Homo sapiens ]
• Official Symbol: TNNT2
• Synonyms: TNNT2; troponin T type 2 (cardiac); cardiomyopathy, hypertrophic 2 , CMH2, troponin T2, cardiac; troponin T, cardiac muscle
• Gene ID: 7139
• mRNA Refseq: NM_000364
• Protein Refseq: NP_000355
• MIM: 191045
• Uniprot ID: P45379
• Chromosome Location: 1q32
• Pathway: Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem
• Function: contributes_to ATPase activity; actin binding; tropomyosin binding; troponin C binding; troponin I binding