Recombinant Human TNIP1, His-tagged

• Cat.No.: TNIP1-31581TH
• Product Overview: Recombinant fragment corresponding to amino acids 94-530 of Human TNIP1 with an N terminal His tag; 458 amino acids with tag, Predicted MWt 51.8 kDa.

Specification

• Description: This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 437 amino acids
• Conjugation: HIS
• Molecular Weight: 51.800kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKA

Gene Information

• Gene Name: TNIP1 TNFAIP3 interacting protein 1 [ Homo sapiens ]
• Official Symbol: TNIP1
• Synonyms: TNIP1; TNFAIP3 interacting protein 1; TNFAIP3-interacting protein 1; ABIN 1; KIAA0113; NAF1; Nef associated factor 1 SNP; VAN; virion associated nuclear shuttling protein
• Gene ID: 10318
• mRNA Refseq: NM_006058
• Protein Refseq: NP_006049
• MIM: 607714
• Uniprot ID: Q15025
• Chromosome Location: 5q32-q33.1
• Pathway: EGFR1 Signaling Pathway, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: protein binding