Recombinant Human TNFSF9, His-tagged

• Cat.No.: TNFSF9-131H
• Product Overview: Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography, 23.8 kDa (222aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: 4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily.4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE
• Purity: > 95% by SDS - PAGE
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 20% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 [ Homo sapiens ]
• Synonyms: TNFSF9; tumor necrosis factor (ligand) superfamily, member 9; CD137L; 4-1BB-L; TNFSF9;tumor necrosis factor (ligand) superfamily, member 9;receptor 4-1BB ligand; homolog of mouse 4-1BB-L; 4-1BBL; 4-1BB ligand; receptor 4-1BB ligand.
• Gene ID: 8744
• mRNA Refseq: NM_003811
• Protein Refseq: NP_003802
• MIM: 606182
• UniProt ID: P41273
• Chromosome Location: 19p13.3
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity; tumor necrosis factor receptor binding