Recombinant Human TNFRSF25, Fc Chimera

• Cat.No.: TNFRSF25-2081H
• Product Overview: Recombinant Human TNFRSF25 is produced inHEK 293 Cells.The cysteine-rich region of human DR3 (aa 25-199) is fused to the Fc portion of human IgG1. MW=55kDa.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 25-199 a.a.
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
• Concentration: 1mg/ml after reconstitution.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
• Application: Can be used together with anti-human IgG1 PAb to detect TL1A.
• Handling: Avoid freeze/thaw cycles.
• Storage And Stability: Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.

Gene Information

• Gene Name: TNFRSF25 tumor necrosis factor receptor superfamily, member 25 [ Homo sapiens ]
• Synonyms: TNFRSF25; tumor necrosis factor receptor superfamily, member 25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; death receptor 3; death receptor beta; lymphocyte associated receptor of death; lymphocyte-associated receptor of death; protein WSL-1; translocating chain-association membrane protein; tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
• Gene ID: 8718
• mRNA Refseq: NM_001039664
• Protein Refseq: NP_001034753
• MIM: 603366
• UniProt ID: Q93038
• Chromosome Location: 1p36.2
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity; tumor necrosis factor receptor activity