Recombinant Human TNFRSF1A, Fc-tagged

• Cat.No.: TNFRSF1A-30481TH
• Product Overview: Recombinant fragment corresponding to amino acids 22-211 of Human TNFRSF1A fused to the Fc portion of Human IgG1; MWt 60 kDa .

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 190 amino acids
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
• Conjugation: Fc
• Molecular Weight: 60.000kDa inclusive of tags
• Biological activity: TNFRSF1A-30481TH blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1μg/ml. Binds Human and Mouse TNF-alpha.
• Form: Lyophilised:Reconstitute with 50μl sterile water to give a final concentration of 1mg/ml.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Store at -20°C, Stable for 6 months at -20°C
• Sequence Similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.

Gene Information

• Gene Name: TNFRSF1A tumor necrosis factor receptor superfamily, member 1A [ Homo sapiens ]
• Official Symbol: TNFRSF1A
• Synonyms: TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; TNFR1; tumor necrosis factor receptor superfamily member 1A; CD120a; TNF R; TNF R I; TNF R55; TNFAR; TNFR60
• Gene ID: 7132
• mRNA Refseq: NM_001065
• Protein Refseq: NP_001056
• MIM: 191190
• Uniprot ID: P19438
• Chromosome Location: 12p13.2
• Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem
• Function: protease binding; protein binding; receptor activity; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity