Recombinant Human TNFRSF19, Fc Chimera

• Cat.No.: TNFRSF19-2435H
• Product Overview: Recombinant cysteine-rich domain of human Troy (TAJ) (aa 1-168) produced inHEK 293 cellsis fused to the Fc portion of human IgG1. 48kDa (under reducing conditions).

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Protein Length: 1-168 a.a.
• Description: Troy, or TAJ, is a member of the tumor necrosis factor receptor (TNFR) family. Troy plays a role in axonal regeneration by forming a functional receptor complex with Nog-66 receptor 1 and LINGO-1. This receptor complex binds myelin inhibitors (Nogo-A, myelin.associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and signals myelin inhibition by activating RhoA. Troy also interacts with TRAF proteins and activates JNK.
• Source/Host: HEK 293 cells.
• Concentration: 1mg/ml after reconstitution.
• Purity: ≥90% (SDS-PAGE).
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute in 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
• Formulation: Lyophilized. Contains PBS.
• Long Term Storage: -20°C.
• Use/Stability: Stable for at least 6 months after receipt when stored at -20°C. Once reconstituted, it is recommended to prepare appropriate aliquots and to store them at -20°C.
• Handling: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF19 tumor necrosis factor receptor superfamily, member 19 [ Homo sapiens ]
• Synonyms: tumor necrosis factor receptor superfamily, member 19; TAJ; TROY; TRADE; TAJ-alpha; TNFRSF19; tumor necrosis factor receptor superfamily member 19; toxicity and JNK inducer; Toxicity and JNK inducer; OTTHUMP00000018114
• Gene ID: 55504
• mRNA Refseq: NM_018647
• Protein Refseq: NP_061117
• MIM: 606122
• UniProt ID: Q9NS68
• Chromosome Location: 13q12.11-q12.3
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity; tumor necrosis factor receptor activity