Recombinant Human TNFRSF14 Protein, His-tagged, Alexa Fluor 647 conjugated
Cat.No. : | TNFRSF14-555HAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant human TNFRSF14 (Leu39-Val202) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
Availability | February 09, 2025 |
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Species : | Human |
Source : | HEK293 |
Tag : | His |
ProteinLength : | Leu39-Val202 |
Description : | Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT/LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated. |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 19.2 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
N-terminal Sequence Analysis : | Leu 39 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name | TNFRSF14 |
Official Symbol | TNFRSF14 |
Synonyms | TNFRSF14; tumor necrosis factor receptor superfamily, member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); tumor necrosis factor receptor superfamily member 14; ATAR; CD270; herpesvirus entry mediator; HVEA; HVEM; LIGHTR; TR2; CD40-like protein; herpesvirus entry mediator A; herpes virus entry mediator A; tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2 |
Gene ID | 8764 |
mRNA Refseq | NM_003820 |
Protein Refseq | NP_003811 |
MIM | 602746 |
UniProt ID | Q92956 |
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Not For Human Consumption!
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