Recombinant Human TNFRSF14, Fc Chimera

• Cat.No.: TNFRSF14-945H
• Product Overview: Recombinant human HVEM-Fc Chimera produced inInsect cellsis a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Fc
• Description: HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.
• Purity: > 98%, by SDS-PAGE and HPLC analysis.
• Endotoxin Level: < 0.1 ng per μg sHVEM/Fc.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Determined by its ability to neutralize 0.25 ng/ml of hTNFβ induced cytotoxicity on murine L929 cells. The expected ED₅₀for this effect is 1.3-1.9 μg/ml of HVEM-Fc.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted HVEM-Fc is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles.
• nullValue_other: Cytokine-cytokine receptor interaction; Signaling in Immune system

Gene Information

• Gene Name: TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [ Homo sapiens ]
• Synonyms: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily, member 14; CD40-like protein; herpesvirus entry mediator A; tumor necrosis factor receptor-like gene2; OTTHUMP00000000866; Herpesvirus entry mediator A; Tumor necrosis factor receptor-like 2
• Gene ID: 8764
• mRNA Refseq: NM_003820
• Protein Refseq: NP_003811
• MIM: 602746
• UniProt ID: Q92956
• Chromosome Location: 1p36.3-p36.2
• Function: tumor necrosis factor receptor activity; transmembrane receptor activity; protein binding