Recombinant Human TNFRSF13B, Fc-tagged

• Cat.No.: TNFRSF13B-1683H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member of the tumor necrosis factor-receptor superfamily and is expressed in B-lymphocytes and may act to regulate humoral immunity. TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL).
• Molecular Weight: The recombinant mature human TACI/Fc is a disulfide-linked homodimeric protein. Based on N-terminal sequencing, the recombinant protein has Ser 2 of human TACI at the amino-terminus. The reduced human TACI/Fc monomer has a calculated molecular mass of 45.2 kDa. In SDS-PAGE, the recombinant TACI/Fc preparation showed an approximately 51 kDa band and an approximately 40 kDa doublet. The presence of multiple bands in the preparation is likely the result of heterogenous glycosylation.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Biological Activity: The biological activity of Human Transmembrane Activator and CAML Interactor is determined by its ability to block human BAFF induced T2B cell survival assay using a concentration range of 1.0-3.0 ug/ml.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [ Homo sapiens ]
• Synonyms: TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; CVID; TACI; CD267; FLJ39942; MGC39952; MGC133214; TNFRSF14B; Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor; OTTHUMP00000065442; CD267 antigen; tumor necrosis factor receptor 13B
• Gene ID: 23495
• mRNA Refseq: NM_012452
• Protein Refseq: NP_036584
• MIM: 604907
• UniProt ID: O14836
• Chromosome Location: 17p11.2
• Pathway: Cytokine-cytokine receptor interaction; Primary immunodeficiency
• Function: protein binding; receptor activity