Recombinant Human TNFRSF10B Protein (Met1-Glu182), C-Fc tagged

• Cat.No.: TNFRSF10B-5248H
• Product Overview: Recombinant human CD262/TNFRSF10B/TRAIL-R2 (Met1-Glu182) fused with the C-terminal Fc tag was expressed in mammalian cells.

Specification

• Source: Mammalian cells
• Species: Human
• Tag: Fc
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 46.35 kDa
• Protein length: Met1-Glu182
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.4.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens (human) ]
• Official Symbol: TNFRSF10B
• Synonyms: TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor (killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5
• Gene ID: 8795
• mRNA Refseq: NM_003842
• Protein Refseq: NP_003833
• MIM: 603612
• UniProt ID: O14763

Reviews

08/11/2020

The combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

10/07/2018

The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.

03/04/2017

The manufacturer's commitment to providing excellent technical support is highly valuable.

Q&As

How does TNFRSF10B activation induce apoptosis in cancer cells?

Activation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.

Is TNFRSF10B involved in other diseases besides cancer?

TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.

Can TNFRSF10B be used as a diagnostic marker for cancer?

TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.

In what types of cancer is TNFRSF10B expression altered?

TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.

Are there any side effects associated with targeting TNFRSF10B in cancer treatment?

Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.