Recombinant Human TMIGD1 Protein (Met1-Pro220), MIgG1 Fc-tagged

• Cat.No.: TMIGD1-599H
• Product Overview: Recombinant Human TMIGD1 Protein (NP_996663.1) (Met1-Pro220) was produced by HEK293 Cells expression system. This protein was expressed with the Fc region of mouse IgG1 at the C-terminus.

Specification

• Description: The transmembrane and immunoglobulin domain-containing 1 (TMIGD1) is a novel tumor suppressor that is highly expressed in normal renal tubular epithelial cells, but it is downregulated in human renal cancer. TMIGD1 as a novel candidate tumor suppressor gene and provides important insight into pathobiology of RCC that could lead to a better diagnosis and possible novel therapy for RCC. TMIGD1 controls cell migration, cell morphology, and protects renal epithelial cells from oxidative- and nutrient-deprivation-induced cell injury. TMIGD1 as a novel cell adhesion molecule expressed in kidney epithelial cells that protects kidney epithelial cells from oxidative cell injury to promote cell survival.
• Source: HEK293
• Species: Human
• Tag: mFc
• Predicted N Terminal: Val 30
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant human TMIGD1 consists of 425 amino acids and predicts a molecular mass of 47.5 kDa.
• Protein length: Met1-Pro220
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: TMIGD1 transmembrane and immunoglobulin domain containing 1 [ Homo sapiens ]
• Official Symbol: TMIGD1
• Synonyms: TMIGD1; TMIGD; UNQ9372; AWKS9372
• Gene ID: 388364
• mRNA Refseq: NM_206832
• Protein Refseq: NP_996663
• UniProt ID: Q6UXZ0