Recombinant Human TGM2 protein, His-tagged

• Cat.No.: TGM2-02H
• Product Overview: Recombinant Human TGM2 protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT.
• Molecular Mass: 79.7 kDa
• Protein length: 1-687aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAEELVL ERCDLELETN GRDHHTADLC REKLVVRRGQ PFWLTLHFEG RNYEASVDSL TFSVVTGPAP SQEAGTKARF PLRDAVEEGD WTATVVDQQD CTLSLQLTTP ANAPIGLYRL SLEASTGYQG SSFVLGHFIL LFNAWCPADA VYLDSEEERQ EYVLTQQGFI YQGSAKFIKN IPWNFGQFED GILDICLILL DVNPKFLKNA GRDCSRRSSP VYVGRVVSGM VNCNDDQGVL LGRWDNNYGD GVSPMSWIGS VDILRRWKNH GCQRVKYGQC WVFAAVACTV LRCLGIPTRV VTNYNSAHDQ NSNLLIEYFR NEFGEIQGDK SEMIWNFHCW VESWMTRPDL QPGYEGWQAL DPTPQEKSEG TYCCGPVPVR AIKEGDLSTK YDAPFVFAEV NADVVDWIQQ DDGSVHKSIN RSLIVGLKIS TKSVGRDERE DITHTYKYPE GSSEEREAFT RANHLNKLAE KEETGMAMRI RVGQSMNMGS DFDVFAHITN NTAEEYVCRL LLCARTVSYN GILGPECGTK YLLNLNLEPF SEKSVPLCIL YEKYRDCLTE SNLIKVRALL VEPVINSYLL AERDLYLENP EIKIRILGEP KQKRKLVAEV SLQNPLPVAL EGCTFTVEGA GLTEEQKTVE IPDPVEAGEE VKVRMDLLPL HMGLHKLVVN FESDKLKAVK GFRNVIIGPA
• Purity: > 85%
• Applications: SDS-PAGE
• Storage: Can be stored at 2 centigrade to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: TGM2 transglutaminase 2 [ Homo sapiens (human) ]
• Official Symbol: TGM2
• Synonyms: Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine gamma-glutamyltransferase 2; G[a]h; TG2; TGase2; Ttg; tTGas
• Gene ID: 7052
• mRNA Refseq: NM_004613
• Protein Refseq: NP_004604
• MIM: 190196
• UniProt ID: P21980