Recombinant Human TGFB1 Protein, Mature chain, Tag Free, Biotinylated

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Description :	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Source :	HEK293
Species :	Human
Tag :	Non
Protein length :	Mature chain
Conjugation/Label :	Biotin
Form :	Lyophilised
Endotoxin :	Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg).
Notes :	FOR RESEARCH USE ONLY (RUO).
Storage :	Upon reconstitution, this cytokine can be stored in working aliquots at 2 to 8 centigrade for one month, or at -20 centigrade for six months. Avoid repeated freeze/thaw cycles.
Storage Buffer :	Lyophilised from 0.2 μm filtered PBS solution pH 7.4.
Reconstitution :	Upon receipt a quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Gene Name	TGFB1 transforming growth factor, beta 1 [ Homo sapiens (human) ]
Official Symbol	TGFB1
Synonyms	TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB;
Gene ID	7040
mRNA Refseq	NM_000660
Protein Refseq	NP_000651
MIM	190180
UniProt ID	P01137