Recombinant Human Tetra-Ubiquitin Protein (K48-Linked), Fluorescein-Labeled

• Cat.No.: Tetra-Ubiquitin-42H
• Product Overview: Recombinant Human Tetra-Ubiquitin Protein (K48-Linked), Fluorescein-Labeled without tag was expressed in E. coli

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Poly-ubiquitylation of target proteins through linkage at K48 is the most thoroughly studied of the various ubiquitin chain linkages. It is now clear that many, if not all, poly-Ub chain topologies are likely to play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkages remain a critical pathway for cells to maintain protein homeostasis and remain intriguing for the study of DUBs that play a role in regulating degradation, as well as the proteasome itself. These tetra-ubiquitin chains are generated by the enzymatic linkage of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains a Lys48 to Arg substitution limiting chain length. The fluorescein moiety is attached to a single, non-lysine site in the proximal ubiquitin.
• Molecular Mass: 34,678.3 Da
• Storage: At -80 centigrade, avoid freeze/thaw cycles

Gene Information

• Official Symbol: Tetra-Ubiquitin
• Synonyms: Tetra-Ubiquitin