Recombinant Human TDP1 Protein, His-Tagged

• Cat.No.: TDP1-01H
• Product Overview: Recombinant human TDP1 protein, His-tagged was expressed in Baculovirus

Specification

• Description: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
• Source: Baculovirus
• Species: Human
• Tag: His
• Applications: SDS-PAGE
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Purity: > 90% by SDS-PAGE
• Storage Buffer: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
• Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by absorbance at 280nm)
• Molecular Mass: 69.5 kDa (617aa)
• Protein length: 1-608aa

Gene Information

• Gene Name: TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens (human) ]
• Official Symbol: TDP1
• Synonyms: tyrosyl-DNA phosphodiesterase 1 isoform a, TDP1, Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1
• Gene ID: 55775
• mRNA Refseq: NM_001008744.2
• Protein Refseq: NP_060789.2
• UniProt ID: Q9NUW8
• MIM: 607198