TDP1
-
Official Full Name
tyrosyl-DNA phosphodiesterase 1 -
Overview
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. -
Synonyms
TDP1;tyrosyl-DNA phosphodiesterase 1;FLJ11090;SCAN1;AI838772;AW493413;MGC104252;MGC112732;RP24-311F12.2;TYDP;TYDP1_HUMAN;Tyr-DNA phosphodiesterase 1;OTTHUMP00000244881;OTTHUMP00000244883;OTTHUMP00000244885;OTTHUMP00000244892
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Insect Cell
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- HEK293 cells
- In Vitro Cell Free System
- His
- His&GST
- Non
- Myc&DDK
- GST
- Flag
- His&Fc&Avi
Involved Pathway
TDP1 involved in several pathways and played different roles in them. We selected most pathways TDP1 participated on our site, such as DNA Double-Strand Break Repair,DNA Repair,Nonhomologous End-Joining (NHEJ), which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | POLI,GEN1,MGMT,KIAA0146,PPP4R2A,INO80E,ALKBH2,PAXIP1,YY1,ERCC8 |
| DNA Double-Strand Break Repair | KDM4B,FAM175A,PARP2,EME2,SMARCA5,EYA2,HUS1,BAZ1B,DNA2,PPP4R2A |
| Nonhomologous End-Joining (NHEJ) | RIF1,TDP2B,TDP2,PAXIP1 |
Protein Function
TDP1 has several biochemical functions, for example, 3-tyrosyl-DNA phosphodiesterase activity,double-stranded DNA binding,exonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP1 itself. We selected most functions TDP1 had, and list some proteins which have the same functions with TDP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | LRPPRC,TEN1,TREX1,FBXO18,YBX1,SSBP3,MCM4,HNRNPK,XRCC3,RPA4 |
| exonuclease activity | FEN1,RAD9,REX1,XRN1,EXO5,DOM3Z,CNOT6,AEN,REXO4,REXO1L1 |
| double-stranded DNA binding | FEN1,HMGB2,RAD51AP1,HMGB3,SAFB,HNRPDL,APTX,IFI16,MCM10,PYDC3 |
| protein binding | ZNF385C,NDUFS7,PAFAH1B1,RUSC1,SFRP5,EIF4A2,VPS33B,SIP1,GM885,CALCRL |
Interacting Protein
TDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP1.
XRCC1;ssdna_dcdg;TRIM33;H2AFX;ATM
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