Recombinant Human TDP1 Protein, Flag-tagged

• Cat.No.: TDP1-3327H
• Product Overview: Recombinant Human TDP1 Protein, Transcript Variant 2, is produced by HEK293T expression system. This protein is fused with a Flag tag.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Description: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
• Form: PBS buffer
• Molecular Mass: 68 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining

Gene Information

• Gene Name: TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens ]
• Official Symbol: TDP1
• Synonyms: TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; tyr-DNA phosphodiesterase 1; MGC104252
• Gene ID: 55775
• mRNA Refseq: NM_001008744
• Protein Refseq: NP_001008744
• MIM: 607198
• UniProt ID: Q9NUW8