Description :	The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Source :	HEK293 cells
Species :	Human
Tag :	Flag
Form :	PBS buffer
Molecular Mass :	68 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining

Gene Name	TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens ]
Official Symbol	TDP1
Synonyms	TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; tyr-DNA phosphodiesterase 1; MGC104252;
Gene ID	55775
mRNA Refseq	NM_001008744
Protein Refseq	NP_001008744
MIM	607198
UniProt ID	Q9NUW8

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Cat.No. :	TDP1-3327H
Product Overview :	Recombinant Human TDP1 Protein, Transcript Variant 2, is produced by HEK293T expression system. This protein is fused with a Flag tag.

Recombinant Human TDP1 Protein, Flag-tagged