Recombinant Human TCEB2

• Cat.No.: TCEB2-30816TH
• Product Overview: Recombinant full length Human TCEB2 protein , predicted MWt: 13.1 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• ProteinLength: 118 amino acids
• Description: This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
• Molecular Weight: 13.100kDa
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 0.02% PMSF, 20% Glycerol
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCIEPFSSPPELP DVMKPQDSGS SANEQAVQ
• Sequence Similarities: Contains 1 ubiquitin-like domain.

Gene Information

• Gene Name: TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) [ Homo sapiens ]
• Official Symbol: TCEB2
• Synonyms: TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B); transcription elongation factor B polypeptide 2; SIII
• Gene ID: 6923
• mRNA Refseq: NM_007108
• Protein Refseq: NP_009039
• MIM: 600787
• Uniprot ID: Q15370
• Chromosome Location: 16p12.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem
• Function: protein binding