TCEB2
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Official Full Name
transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) -
Overview
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. -
Synonyms
TCEB2;transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B);transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B);transcription elongation factor B polypeptide 2;SIII;EloB;ELOB_HUMAN;Elongin 18 kDa subunit;Elongin B;Elongin-B;RNA polymerase II transcription factor SIII subunit B;SIII p18;TCEB 2;Transcription elongation factor B (SIII) polypeptide 2;OTTHUMP00000205114;OTTHUMP00000205115;OTTHUMP00000205116;elongin, 18-kD subunit;RNA polymerase II transcription
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCEB2-3154H | Recombinant Human TCEB2, GST-tagged | E.coli | Human | GST | 1-118aa | |
| TCEB2-3078H | Recombinant Human TCEB2 protein, His-tagged | E.coli | Human | His | 1-118 aa | |
| TCEB2-16551M | Recombinant Mouse TCEB2 Protein | Mammalian Cells | Mouse | His |
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| TCEB2-30816TH | Recombinant Human TCEB2 | E.coli | Human | Non | 118 amino acids |
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| TCEB2-360H | Recombinant Human TCEB2 protein | E.coli | Human | Non | 1-118 aa |
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| TCEB2-5987R | Recombinant Rat TCEB2 Protein | Mammalian Cells | Rat | His |
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| TCEB2-7253Z | Recombinant Zebrafish TCEB2 | Mammalian Cells | Zebrafish | His |
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| TCEB2-1187HCL | Recombinant Human TCEB2 293 Cell Lysate | HEK293 | Human | Non |
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| TCEB2-1188HCL | Recombinant Human TCEB2 293 Cell Lysate | HEK293 | Human | Non |
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| TCEB2-5646R | Recombinant Rat TCEB2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TCEB2-5646R-B | Recombinant Rat TCEB2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TCEB2-9075M | Recombinant Mouse TCEB2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TCEB2-9075M-B | Recombinant Mouse TCEB2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TCEB2 involved in several pathways and played different roles in them. We selected most pathways TCEB2 participated on our site, such as HIF- signaling pathway,Ubiquitin mediated proteolysis,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCEB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | TFRC,PFKL,IL6R,AKT2,ANGPT1,TEK,EPO,FLT1,PGK1,CAMK2G |
| Renal cell carcinoma | PIK3R2,CUL2,PIK3CG,AHA-1,ARNT2,PAK3,SLC2A1,PIK3CB,MAPK1,AKT2 |
| Ubiquitin mediated proteolysis | UBE2Q2,MGRN1B,RBX1,ANAPC2,AIRE,RHOBTB2A,RHOBTB1,UBE2D2L,FZR1A,SAE1 |
| Pathways in cancer | STK4,ROCK2,FGF9,NFKB2,STAT1,ITGA2,SPI1,TRAF5,MITF,VHL |
Protein Function
TCEB2 has several biochemical functions, for example, protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCEB2 itself. We selected most functions TCEB2 had, and list some proteins which have the same functions with TCEB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HP,LENG1,TESC,NOD1,PSMD7,SUGP1,SPG20,HSPA4,DIABLO,TUBB2B |
| ubiquitin protein ligase binding | UBE2U,CUL5,HERC2,AICDA,TRAF6,TSG101,LTBR,UBE2Z,KDM4A,AMBRA1 |
Interacting Protein
TCEB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCEB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCEB2.
VHL;TCEB1
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References
- Yerlikaya, A; Okur, E; et al. A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line. JOURNAL OF PROTEOMICS 113:315-325(2015).
- Chen, J; Ruan, XY; et al. Antitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor. TUMOR BIOLOGY 35:10993-11003(2014).
