Recombinant Human TAPBP Protein, MYC/DDK-tagged

• Cat.No.: TAPBP-122H
• Product Overview: Recombinant human TAPBP protein, fused to MYC/DDK-tag at C-terminal, was expressed in HEK293.

Specification

• Description: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 45.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TAP binding protein [ Homo sapiens ]
• Official Symbol: TAPBP
• Synonyms: NGS17; TAPA; TPN; TPSN
• Gene ID: 6892
• mRNA Refseq: NM_003190.4
• Protein Refseq: NP_003181.3
• MIM: 601962
• UniProt ID: O15533