TAPBP
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Official Full Name
TAP binding protein (tapasin) -
Overview
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. -
Synonyms
TAPBP;TAP binding protein (tapasin);tapasin;TAPA;NGS 17;NGS-17;NGS17;TAP associated protein;TAP binding protein;TAP BP;TAP-associated protein;TAP-binding protein;TPN;TPSN;TPSN_HUMAN
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli expression system
- E.coli
- HEK293T
- Non
- His
- Myc&DDK
- N-His&C-Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAPBP-31499TH | Recombinant Human TAPBP | Wheat Germ | Human | Non | 104 amino acids |
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| TAPBP-3274C | Recombinant Chicken TAPBP | Mammalian Cell | Chicken | His |
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| TAPBP-4512C | Recombinant Chicken TAPBP | Mammalian Cell | Chicken | His |
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| TAPBP-4616R | Recombinant Rhesus monkey TAPBP Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| TAPBP-688H | Recombinant Human TAPBP Protein, His-tagged | HEK293 | Human | His | 1-414 a.a. |
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| TAPBP-8610Z | Recombinant Zebrafish TAPBP | Mammalian Cell | Zebrafish | His |
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| RFL4366HF | Recombinant Full Length Human Tapasin(Tapbp) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (21-448) |
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| RFL5354GF | Recombinant Full Length Chicken Tapasin(Tapbp) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length of Mature Protein (16-430) |
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| TAPBP-122H | Recombinant Human TAPBP Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| TAPBP-154H | Recombinant Human TAPBP Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| TAPBP-4432H | Recombinant Human TAPBP protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 21-414aa |
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| TAPBP-4432R | Recombinant Rhesus Macaque TAPBP Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| TAPBP-4432R-B | Recombinant Rhesus Macaque TAPBP Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Tapbp-6292M | Recombinant Mouse Tapbp Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
TAPBP involved in several pathways and played different roles in them. We selected most pathways TAPBP participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAPBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HLA-DOA,KLRD1,HLA-DRB1,HLA-A,KIR2DL4,HLA-DRB3,RFX5,B2M,H2-AA,CTSB |
Protein Function
TAPBP has several biochemical functions, for example, MHC class I protein binding,TAP1 binding,TAP2 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAPBP itself. We selected most functions TAPBP had, and list some proteins which have the same functions with TAPBP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP2 binding | HLA-F,TAP1 |
| unfolded protein binding | DNAJA3A,HSPA5,GRPEL1,GRPEL2,RP2,SRSF12,CLN3,TOR1A,SSUH2.2,CALRL2 |
| peptide antigen binding | MHC1UKA,HLA-DRA,MHC1UIA,AZGP1,HLA-DRB1,HLA-DQB1,H2-AB1,MHC1ZKA,MAML1,MHC1ZFA |
| peptide antigen-transporting ATPase activity | TAP2 |
| protein binding | PSMA2,ZCCHC7,ASCC1,DNAJB9,DTX3,TSNAX,CRLF3,S1PR3,TMBIM6,SIM1 |
| TAP1 binding | TAP2,HLA-F,TAP1 |
| MHC class I protein binding | VCP,CD8B,ATP5B,BCAP31,CD8A,Pilrb1,CD244,LILRB1,LILRB2,TAP1 |
Interacting Protein
TAPBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAPBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TAPBP.
TAP1;TAP2
Resources
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References
- Hulpke, S; Baldauf, C; et al. Molecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing. FASEB JOURNAL 26:5071-5080(2012).
- Rizvi, SM; Raghavan, M; et al. Mechanisms of Function of Tapasin, a Critical Major Histocompatibility Complex Class I Assembly Factor. TRAFFIC 11:332-347(2010).
