Recombinant Human suppressor of IKBKE 1, His-tagged

• Cat.No.: SIKE1-521H
• Product Overview: SIKE1, 1-207aa Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-207 a.a.
• Description: SIKE interacts with IKK-epsilon and TBK1 and acts as a suppressor of TLR3 and virus-triggered interferon activation pathways. Recombinant human SIKE1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT
• Molecular Mass: 26.1 kDa (230aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSCTIEK ILTDAKTLLE RLREHDAAAE SLVDQSAALH RRVAAMREAG TALPDQYQED ASDMKDMSKY KPHILLSQEN TQIRDLQQEN RELWISLEEH QDALELIMSK YRKQMLQLMV AKKAVDAEPV LKAHQSHSAE IESQIDRICE MGEVMRKAVQ VDDDQFCKIQ EKLAQLELEN KELRELLSIS SESLQARKEN SMDTASQAIK
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SIKE1 suppressor of IKBKE 1 [ Homo sapiens ]
• Official Symbol: SIKE1
• Synonyms: SIKE; RP5-1000E10.4
• Gene ID: 80143
• mRNA Refseq: NM_025073.2
• Protein Refseq: NP_079349.2
• MIM: 611656
• UniProt ID: Q9BRV8
• Chromosome Location: 1p13.2
• Pathway: Immune System, organism-specific biosystem;Innate Immune System, organism-specific biosystem;RIG-I-like receptor signaling pathway, organism-specific biosystem;RIG-I-like receptor signaling pathway, conserved biosystem;RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem;TRAF3-dependent IRF activation pathway, organism-specific biosystem;TRAF6 mediated IRF7 activation, organism-specific biosystem
• Function: protein binding