Recombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged

• Cat.No.: SOCS3-6938H
• Product Overview: RecombinantHuman SOCS3 protein was expressed as GST-tagged fusion protein by E. coli andpurified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: Thisgene encodes a member of the suppressor of cytokine signaling, family. SSIfamily members are cytokine-inducible negative regulators of cytokinesignaling. The expression of this gene is induced by various cytokines,including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by thisgene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase.
• Antigen peptide: 1-225aa
• Expression Vector: PGEX-4T
• Full length: True
• Reconstitution: 1M PBS (58mMNa2HPO4,17mM NaH2PO4, 68mM NaCl, pH 8.0) added with 100mM GSH and 1% TritonX-100,15%glycerol.
• Storage: The protein is stored in PBS buffer at -20°C. Repeated freeze-thaw cycles should be avoided.

Gene Information

• Gene Name: SOCS3 suppressor ofcytokine signaling 3 [ Homo sapiens ]
• Official Symbol: SOCS3
• Synonyms: SOCS3;suppressor of cytokine signaling 3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3;CIS-3; STAT-induced STAT inhibitor 3; cytokine-induced SH2 protein 3;cytokine-inducible SH2 protein 3; MGC71791
• Gene ID: 9021
• mRNA Refseq: NM_003955
• Protein Refseq: NP_003946
• MIM: 604176
• UniProt ID: P35270
• Chromosome Location: 2p14-p12
• Pathway: ATF-2 transcription factor network;Adaptive Immune System; Adipocytokine signaling pathway; Adipogenesis; ClassI MHC mediated antigen processing & presentation; Cytokine Signaling inImmune system; ECS complex; EGFR1 Signaling Pathway; EPO signaling pathway;Growth hormone receptor signaling; Hepatitis C; Herpes simplex infection;IL-2 Signaling Pathway; IL-3 Signaling Pathway; IL-4 signaling Pathway; IL-6Signaling Pathway
• Function: protein kinase inhibitor activity