Recombinant Human Stress-induced-phosphoprotein 1, His-tagged

• Cat.No.: STIP1-1810H
• Product Overview: Recombinant human STI1, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 64.8 kDa (563aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Stress-induced-phosphoprotein1 (STI1), also known as HOP, belongs to the large group of co-chaperones. The main function of STI1 is to link Hsp70 and Hsp90 together. But recent investigations indicate that it also modulates the chaperone activities of the linked proteins and possibly interacts with other chaperones and proteins. It forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84, as well as interacting with PACRG.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLA ERKFMNPFNM PNLYQKLESD PRTRTLLSDP TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSM DEEEEIATPP PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDTALKHYDK AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 20% glycerol, 1mM EDTA, 0.2mM PMSF.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: STIP1 stress-induced-phosphoprotein 1 [ Homo sapiens ]
• Synonyms: STIP1; stress-induced-phosphoprotein 1; HOP; P60; STI1; STI1L; IEF-SSP-3521; Hsp70/Hsp90-organizing protein; Transformation-sensitive protein IEF SSP 3521; NY-REN-11 antigen; stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)
• Gene ID: 10963
• mRNA Refseq: NM_006819
• Protein Refseq: NP_006810
• MIM: 605063
• UniProt ID: P31948
• Chromosome Location: 11q13
• Pathway: Prion diseases
• Function: protein binding