STIP1
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Official Full Name
stress-induced-phosphoprotein 1 -
Overview
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1;;MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding;both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase;activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and;Masison, 2005 (PubMed 16100115)). -
Synonyms
STIP1;stress-induced-phosphoprotein 1;HOP;Hsp70/Hsp90 organizing protein;STI1;NY-REN-11 antigen;Hsp70/Hsp90-organizing protein;hsc70/Hsp90-organizing protein;renal carcinoma antigen NY-REN-11;transformation-sensitive protein IEF SSP 3521;P60;STI1L;IEF-SSP-3521
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Insect Cells
- GST
- GST&His
- His
- Flag
- Non
- DDK&Myc
- Avi&Fc&His
- His&MBP
- His&SUMO
Involved Pathway
STIP1 involved in several pathways and played different roles in them. We selected most pathways STIP1 participated on our site, such as Prion diseases, which may be useful for your reference. Also, other proteins which involved in the same pathway with STIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prion diseases | Hc,PRNP,PRKACB,LOC100033925,NCAM2,C1QC,PRKACG,HSPA1A,NCAM1,C8A |
Protein Function
STIP1 has several biochemical functions, for example, Hsp70 protein binding,chaperone binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STIP1 itself. We selected most functions STIP1 had, and list some proteins which have the same functions with STIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Hsp70 protein binding | CDK1,FAM119A,TFRC,MVD,PACRG,DNAJC10,ST13,C11orf73,CDKN1B,BAG6 |
| protein binding | FGF21,ARNTL1B,SAP30L,TRIM26,MFN2,GGT1,PRAME,SLC6A20B, Cd79b,IL6ST |
| chaperone binding | ATP1A3,UBL4A,UBL4,SDF2L1,RNF207,HSP104,BAG5,HSPD1,SOD1,TBCE |
| protein C-terminus binding | BLOC1S2A,DBNL,NEFL,CDC20,SHANK1,ARL6IP5,SIAH1,MYO1C,TFCP2,VPS36 |
| poly(A) RNA binding | TRIM25,ZCCHC24,NCL,MCAT,CHCHD1,NGDN,MRPL4,TSNAX,FBL,RBPMS |
Interacting Protein
STIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STIP1.
HSP90AA1;NR3C1;VCAM1;EGFR;ACD;CDC37L1;CCDC117
Resources
Research Area
Adaptor ProteinsNegative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
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References
