Recombinant Human STK3, GST-tagged, Active

• Cat.No.: STK3-437H
• Product Overview: Recombinant full-length human STK3 was expressed by baculovirus inSf9insect cells using a N-terminal GST tag. MW = 87 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: STK3, also known as MST2, encodes a protein of 491-amino acid which contains an N-terminal catalytic domain characteristic of STKs. STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall. RAF1 has been shown to counteract apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). STK3 is a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand. STK3 activation presumably allows cells to resist unfavorable environmental conditions.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: STK3 serine/threonine kinase 3 (STE20 homolog, yeast) [ Homo sapiens ]
• Synonyms: STK3; serine/threonine kinase 3 (STE20 homolog, yeast); KRS1; MST2; FLJ90748; serine/threonine kinase 3; serine/threonine kinase 3 (Ste20, yeast homolog); EC 2.7.11.1; MST-2; Mammalian STE20-like protein kinase 2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1; Serine/threonine-protein kinase 3
• Gene ID: 6788
• mRNA Refseq: NM_006281
• Protein Refseq: NP_006272
• MIM: 605030
• UniProt ID: Q13188
• Chromosome Location: 8q22.2
• Pathway: MAPK signaling pathway
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein dimerization activity; protein serine/threonine kinase activity; transferase activity