STK3
-
Official Full Name
serine/threonine kinase 3 -
Overview
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein;functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal;portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which;promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have;been found for this gene. -
Synonyms
STK3;serine/threonine kinase 3;serine/threonine kinase 3 (Ste20, yeast homolog);serine/threonine-protein kinase 3;KRS1;MST2;MST-2;STE20-like kinase MST2;mammalian STE20-like protein kinase 2;serine/threonine-protein kinase Krs-1;serine/threonine
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- Insect (sf21)
- His
- GST
- Non
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
STK3 involved in several pathways and played different roles in them. We selected most pathways STK3 participated on our site, such as MAPK signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAP4K2,RPS6KA3B,IKBKB,MRAS,TAB2,PLA2G4F,PTPRR,CACNB3,CDC42L2,MAP2K2B |
| Hippo signaling pathway | WWC1,DLG1,CRB1,AMH,FGF1,WNT9A,APC,BMP7,PPP1CA,PPP1CB |
Protein Function
STK3 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK3 itself. We selected most functions STK3 had, and list some proteins which have the same functions with STK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activator activity | CALM1,CDK5R1,STRADA,MAP2K1,MAP2K2,CAB39,STK4,LTF,PARP16,CALM2 |
| MAP kinase kinase kinase activity | TAOK1,MOS,KIAA1804,ZAK,BRAF,MAP3K13,STK4,TAOK3,EGFR,MAP3K1 |
| protein serine/threonine kinase activity | PRKCHA,ATM,MAPK14,RAF1,MAP3K8,MOS,PRPF4B,PAK3,SMOK3A,CSNK2A1 |
| protein binding | BAAT,CDKN2A,MAGOH,LDHA,EXOC1,PLOD3,PCDH18B,SERPINA1A,VPS52,EIF3M |
| protein kinase activity | NEK5,TRIM28,cka1,CCND1,JAK2B,CAMK1DA,PRKCD,TNIKB,TSSK5,KDRL |
| protein dimerization activity | PRKRIR,EBF3A,HES2.2,ATOH1A,MXD1,MYCS,TFEB,MEF2D,MYCL1,NHLH1 |
| magnesium ion binding | AASDHPPT,ENO1,IDH3B,RPS6KA3B,PPA1A,INPP1,PGM2,NLK,IRAK4,HPRT1 |
| ATP binding | EPHB2,ACSM1,CLK3,ABCB1A,MARK2,MYLK3,SMOK2B,TDRD12,ACSS2,HELQ |
Interacting Protein
STK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK3.
SAV1;STK4
Resources
Related Services
Related Products
References
- Hammer, A; Oladimeji, P; et al. Phosphorylation of tyrosine 285 of PAK1 facilitates beta PIX/GIT1 binding and adhesion turnover. FASEB JOURNAL 29:943-959(2015).
- Kamato, D; Rostam, MA; et al. Transforming growth factor beta-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. JOURNAL OF PHARMACY AND PHARMACOLOGY 66:1722-1733(2014).
