Recombinant Human STK24 Protein (M1-H443), GST tagged

• Cat.No.: STK24-1155H
• Product Overview: Recombinant Human GST-TEV-MST3(M1-H443 end) Protein was expressed in Insect cell.

Specification

• Description: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein length: M1-H443
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: STK24 serine/threonine kinase 24 [ Homo sapiens (human) ]
• Official Symbol: STK24
• Synonyms: STK24; serine/threonine kinase 24; serine/threonine kinase 24 (Ste20, yeast homolog); serine/threonine-protein kinase 24; MST 3; MST3; MST3B; STE20; STE20 like kinase 3; sterile 20 like kinase 3; STK3; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; mammalian STE20-like protein kinase 3; serine/threonine kinase 24 (STE20 homolog, yeast)
• Gene ID: 8428
• mRNA Refseq: NM_001032296
• Protein Refseq: NP_001027467
• MIM: 604984
• UniProt ID: Q9Y6E0