STK24
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Official Full Name
serine/threonine kinase 24 -
Overview
The yeast Sterile 20 gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In;mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation.;Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory;domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM;603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain;without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 (PubMed;10644707)). -
Synonyms
STK24;serine/threonine kinase 24;serine/threonine kinase 24 (Ste20, yeast homolog);serine/threonine-protein kinase 24;MST 3;MST3;MST3B;STE20;STE20 like kinase 3;sterile 20 like kinase 3;STK3;STE20-like kinase 3;STE20-like kinase MST3;sterile
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- Insect Cell
- Insect (sf21)
- HEK293
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
STK24 involved in several pathways and played different roles in them. We selected most pathways STK24 participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | PRKAR1B,SPNA2,ATM,PIK3R3,PIK3R1,BIRC2,TNFSF10,CAPN2A,TP53,DAPK3 |
| Programmed Cell Death | PANK1A,CASP6L1,DBNLA,HMGB2A,DIABLOB,DSG1,GZMC,GZMF,RIPK3,DSG2 |
| Apoptotic cleavage of cellular proteins | PKP1,DBNLA,PLECA,LMNB1,DSP,DSG1,CASP8L1,VIML,BMX,CTNNB2 |
| Apoptotic execution phase | DSP,DSG2,PKP1,STK24A,SATB1,ADD1,DBNLA,SPNA2,STK24B,DSG1 |
Protein Function
STK24 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK24 itself. We selected most functions STK24 had, and list some proteins which have the same functions with STK24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FZD5,TXLNG,IFIT3,DYNLL2,DMBT1,RAPGEF4,PTPRS,CBX7,B2M,ATP6V1B2 |
| protein kinase activity | NEK2,IRAK1,MAP2K4A,KDRL,SGK3,PRKACBA,MAP3K11,MAP2K5,BMPR1AA,CAMK1GB |
| ATP binding | LARS,KIFC3,SIK2,AGAP2,ACVR2A,PSMC6,NLRP14,MCCC2,CAMK1D,DHX32 |
| metal ion binding | RAF1A,ADO,C1GALT1,ZNF777,NOX1,PLEKHF2,COL27A1B,PRKD2,EXT2,LNPA |
| protein serine/threonine kinase activity | MAPK11,STK3,BMPR1BB,NEK6,STK16,KALRN,MAPK1,TGFBR1B,CSNK1G1,PRKCBA |
Interacting Protein
STK24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK24 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK24.
PDCD10;STRN3;SLMAP
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References
- Lasota, J; Kowalik, A; et al. Detection of the BRAF V600E Mutation in Colon Carcinoma Critical Evaluation of the Imunohistochemical Approach. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:1235-1241(2014).
- Dugast, E; Kiss-Toth, E; et al. Identification of Tribbles-1 as a Novel Binding Partner of Foxp3 in Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 288:10051-10060(2013).
