Recombinant Human STAT5A protein, His/MBP-tagged

• Cat.No.: STAT5A-341H
• Product Overview: Recombinant Human STAT5A(148-316 aa) fused with His/MBP tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His&MBP
• Form: Liquid in PBS
• Protein length: 148-316 aa
• Purity: SDS-PAGE >90%
• Applications: WB Positive Control
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: STAT5A signal transducer and activator of transcription 5A [ Homo sapiens ]
• Official Symbol: STAT5A
• Synonyms: STAT5A; signal transducer and activator of transcription 5A; STAT5; MGF
• Gene ID: 6776
• mRNA Refseq: NM_003152
• Protein Refseq: NP_003143
• MIM: 601511
• UniProt ID: P42229