Recombinant Human SRY Protein, His-tagged

• Cat.No.: SRY-454H
• Product Overview: Recombinant Human SRY(Met1~Leu204) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Met1~Leu204
• Description: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 27.6kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: SRY sex determining region Y [ Homo sapiens ]
• Official Symbol: SRY
• Synonyms: SRY; sex determining region Y; sex-determining region Y protein; TDF; testis determining factor; testis-determining factor; sex-determining region on Y; sex determining region protein; essential protein for sex determination in human males; TDY; SRXX1; SRXY1
• Gene ID: 6736
• mRNA Refseq: NM_003140
• Protein Refseq: NP_003131
• MIM: 480000
• UniProt ID: Q05066