Recombinant Human SRSF2

• Cat.No.: SRSF2-31385TH
• Product Overview: Recombinant full length human SC35 expressed in a baculovirus system; amino acids 2-221, approximately 25kDa.

Specification

• Description: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.
• Biological activity: 1 unit equals 1 nanogram of purified protein.
• Form: Liquid
• Purity: Immunogen affinity purified
• Storage buffer: pH: 8.00Constituents:0.00584% EDTA, 0.476% HEPES, 0.0077% DTT, 0.55% Ammonium sulphate, 20% Glycerol
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the splicing factor SR family.Contains 1 RRM (RNA recognition motif) domain.
• Tag: Non
• Protein length: 2-221 a.a.
• Full Length: Full L.

Gene Information

• Gene Name: SRSF2 serine/arginine-rich splicing factor 2 [ Homo sapiens ]
• Official Symbol: SRSF2
• Synonyms: SRSF2; serine/arginine-rich splicing factor 2; SFRS2, splicing factor, arginine/serine rich 2; PR264; SC 35; SC35; SFRS2A; SR splicing factor 2
• Gene ID: 6427
• mRNA Refseq: NM_001195427
• Protein Refseq: NP_001182356
• MIM: 600813
• Uniprot ID: Q01130
• Chromosome Location: 17q25.2
• Pathway: Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem
• Function: RNA binding; nucleic acid binding; nucleotide binding; protein binding; transcription corepressor activity