SRSF2
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Official Full Name
serine/arginine-rich splicing factor 2 -
Overview
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. -
Synonyms
SRSF2;serine/arginine-rich splicing factor 2;SFRS2, splicing factor, arginine/serine rich 2;PR264;SC 35;SC35;SFRS2A;SR splicing factor 2;35 kDa;arginine/serine-rich 2;Protein PR264;SC-35;SFRS 2;SFRS2;Splicing component 35 kDa;Splicing component;Splicing factor;Splicing factor arginine/serine rich 2;Splicing factor SC35;Splicing speckle;Splicing speckles;SRp30b;SRSF2_HUMAN;splicing component, 35 kDa;splicing factor, arginine/serine-rich 2
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Sf21 Cells
- Mammalian Cells
- E.coli
- HEK293
- His
- GST&His
- Non
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SRSF2-8495H |
Active Recombinant Human SRSF2, His-tagged
|
Sf21 Cells | Human | His | 4-221 a.a. |
|
| SRSF2-1089C | Recombinant Chicken SRSF2 | Mammalian Cells | Chicken | His |
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| SRSF2-1401H | Recombinant Human SRSF2 protein, His & GST-tagged | E.coli | Human | GST&His | Thr14~Ser221 |
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| SRSF2-31385TH | Recombinant Human SRSF2 | Human | Non | Full L. 2-221 a.a. |
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| SRSF2-4475R | Recombinant Rhesus monkey SRSF2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| SRSF2-5747R | Recombinant Rat SRSF2 Protein | Mammalian Cells | Rat | His |
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| SRSF2-1592HCL | Recombinant Human SRSF2 cell lysate | Human | Non |
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| SRSF2-4291R | Recombinant Rhesus Macaque SRSF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| SRSF2-4291R-B | Recombinant Rhesus Macaque SRSF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SRSF2-5406R | Recombinant Rat SRSF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| SRSF2-5406R-B | Recombinant Rat SRSF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SRSF2 involved in several pathways and played different roles in them. We selected most pathways SRSF2 participated on our site, such as Spliceosome,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | IFNA1,SRSF7B,HLA-DRA,NFKBIAB,CUL1A,BLB1,JAK2A,HLA-E,IL12A,SFRS3B |
| Spliceosome | HNRNPK,FAM120B,TXNL4A,PUF60,SNRNP40,RBM17,PRPF31,CRNKL1,LSM3,SF3A3 |
Protein Function
SRSF2 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,pre-mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF2 itself. We selected most functions SRSF2 had, and list some proteins which have the same functions with SRSF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | RBM28,MXA,HNRNPH1,NADKD1,KIF3CB,RBMS2B,RBMX2,PTBP1A,CELF2,EEF1A1L2 |
| poly(A) RNA binding | QKI,Cstb,NOL12,TIAL1,WDR6,PUS1,DDX27,ZYX,UBE2O,ENO1 |
| transcription corepressor activity | ATN1,BRD7,NR0B2,LOXL2,ZFPM2,RUNX1T1,SSX3,CTCF,HDAC7A,LDB1 |
| protein binding | TTC19,ARHGDIA,CA,DOK1,PAG1,RNF11,PDE6D,GABPA,SNX12,NCKAP1 |
| pre-mRNA binding | RBM22,PTBP1,DDX5,TARBP2 |
Interacting Protein
SRSF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF2.
CIR1;KAT5;ESR2;SRPK1;Srek1;ESR1;NCL;CSNK2A1;CDK6;AIRE
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