Recombinant Human SRPK2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | SRPK2-2663H |
Product Overview : | SRPK2 MS Standard C13 and N15-labeled recombinant protein (NP_872633) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Species : | Human |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. |
Molecular Mass : | 77.5 kDa |
AA Sequence : | MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNSSGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name | SRPK2 SRSF protein kinase 2 [ Homo sapiens (human) ] |
Official Symbol | SRPK2 |
Synonyms | SRPK2; SRSF protein kinase 2; SFRS protein kinase 2; serine/arginine rich splicing factor kinase 2; SFRSK2; SR protein kinase 2; H_RG152G17.1a; H_RG152G17.1b; WUGSC:H_RG152G17.1a; serine kinase SRPK2; SR-protein-specific kinase 2; serine/threonine-protein kinase SRPK2; serine/arginine-rich splicing factor kinase 2; serine/arginine-rich protein-specific kinase 2; FLJ36101; |
Gene ID | 6733 |
mRNA Refseq | NM_182691 |
Protein Refseq | NP_872633 |
MIM | 602980 |
UniProt ID | P78362 |
◆ Recombinant Proteins | ||
Srpk2-6131M | Recombinant Mouse Srpk2 Protein, Myc/DDK-tagged | +Inquiry |
SRPK2-1069H | Recombinant Human SRPK2 Protein (S2-N688), Tag Free | +Inquiry |
SRPK2-001H | Recombinant Human SRSF protein kinase 2 Protein, His tagged | +Inquiry |
SRPK2-15996M | Recombinant Mouse SRPK2 Protein | +Inquiry |
SRPK2-2663H | Recombinant Human SRPK2 Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Cell & Tissue Lysates | ||
SRPK2-1474HCL | Recombinant Human SRPK2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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