Recombinant Human SPIN1 Protein (Met1-Ser262), His tagged

• Cat.No.: SPIN1-5574H
• Product Overview: Recombinant human SPIN1 (Met1-Ser262) fused with His tag was expressed in E. coli.

Specification

• Description: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 30.59 kDa
• Protein length: Met1-Ser262
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SPIN1 spindlin 1 [ Homo sapiens (human) ]
• Official Symbol: SPIN1
• Synonyms: SPIN1; spindlin 1; SPIN; spindlin-1; ovarian cancer-related protein; OCR; spindlin
• Gene ID: 10927
• mRNA Refseq: NM_006717
• Protein Refseq: NP_006708
• MIM: 609936
• UniProt ID: Q9Y657