Recombinant Human sorbin and SH3 domain containing 3, His-tagged

• Cat.No.: SORBS3-407H
• Product Overview: SORBS3, 1-329aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-329 a.a.
• Description: SORBS3 is an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein"s ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human SORBS3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
• Molecular Mass: 39.1 kDa(352aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMADGGSP FLGRRDFVYP SSTRDPSASN GGGSPARREE KKRKAARLKF DFQAQSPKEL TLQKGDIVYI HKEVDKNWLE GEHHGRLGIF PANYVEVLPA DEIPKPIKPP TYQVLEYGEA VAQYTFKGDL EVELSFRKGE HICLIRKVNE NWYEGRITGT GRQGIFPASY VQVSREPRLR LCDDGPQLPT SPRLTAAARS ARHPSSPSAL RSPADPIDLG GQTSPRRTGF SFPTQEPRPQ TQNLGTPGPA LSHSRGPSHP LDLGTSSPNT SQIHWTPYRA MYQYRPQNED ELELREGDRV DVMQQCDDGW FVGVSRRTQK FGTFPGNYVA PV
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SORBS3 sorbin and SH3 domain containing 3 [ Homo sapiens ]
• Official Symbol: SORBS3
• Synonyms: SORBS3; sorbin and SH3 domain containing 3; vinexin; SCAM 1; SH3D4; sorbin and SH3 domain-containing protein 3; vinexin beta (SH3-containing adaptor molecule-1); SCAM1; SCAM-1
• Gene ID: 10174
• mRNA Refseq: NM_001018003
• Protein Refseq: NP_001018003
• MIM: 610795
• UniProt ID: O60504
• Chromosome Location: 8p21.3
• Pathway: Muscle contraction, organism-specific biosystem; Smooth Muscle Contraction, organism-specific biosystem
• Function: protein binding; structural constituent of cytoskeleton; transcription factor binding; vinculin binding