Recombinant Human SNUPN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: SNUPN-5725H
• Product Overview: SNUPN MS Standard C13 and N15-labeled recombinant protein (NP_001036046) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 41.1 kDa
• AA Sequence: MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMENTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: SNUPN snurportin 1 [ Homo sapiens (human) ]
• Official Symbol: SNUPN
• Synonyms: SNUPN; snurportin 1; RNA, U transporter 1, RNUT1; snurportin-1; SNURPORTIN 1; Snurportin1; RNA U transporter 1; RNA, U transporter 1; KPNBL; RNUT1
• Gene ID: 10073
• mRNA Refseq: NM_001042581
• Protein Refseq: NP_001036046
• MIM: 607902
• UniProt ID: O95149