Recombinant Human SMARCA4 Protein, His-tagged

• Cat.No.: SMARCA4-198H
• Product Overview: Recombinant Human SMARCA4 protein, fused with N-terminal His-tag, was expressed in E. coli.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Form: 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v)
• Molecular Mass: 17.1 kDa
• Protein length: 1148-1569
• Purity: >95% by SDS-PAGE
• Storage: Store at -80centigrade. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Homo sapiens ]
• Official Symbol: SMARCA4
• Synonyms: SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SNF2L4; transcription activator BRG1; ATP dependent helicase SMARCA4; BAF190; brahma protein like 1; BRG1; BRM/SWI2 related gene 1; FLJ39786; globa
• Gene ID: 6597
• mRNA Refseq: NM_001128844
• Protein Refseq: NP_001122316
• MIM: 603254
• UniProt ID: P51532
• Chromosome Location: 19p13.3
• Pathway: Direct p53 effectors, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Regulation of retinob
• Function: ATP binding; DNA binding; DNA-dependent ATPase activity; Tat protein binding; androgen receptor binding; helicase activity; histone acetyl-lysine binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; nucleotide bindi

Reviews

02/18/2023

The SMARCA4 protein offers exceptional quality that meets the rigorous demands of experimental research.

11/01/2018

It exhibits exceptional performance in ELISA assays, making it an excellent choice for researchers studying angiopoietins, angiogenesis, or vascular biology.

10/30/2016

Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.

Q&As

Can epigenetic therapies target SMARCA4 alterations?

Epigenetic therapies that modulate gene expression could indirectly affect SMARCA4-altered cancers, though specific targeting remains a challenge.

Are there diagnostic tests for SMARCA4 mutations?

Yes, there are genetic tests available to identify SMARCA4 mutations in tumors, aiding in prognosis and treatment decisions.

Are there ongoing clinical trials focusing on SMARCA4 alterations?

Yes, there are clinical trials exploring new treatment strategies for SMARCA4-altered cancers, aiming to improve patient outcomes.

Is SMARCA4 solely associated with cancer?

No, SMARCA4's functions extend beyond cancer and have implications in various biological processes, including development and differentiation.

How can SMARCA4 mutations influence patient prognosis?

Patients with SMARCA4 mutations in their tumors often face a poorer prognosis, which necessitates tailored treatment approaches.