Recombinant Human SLC19A1 Protein (V2-Q591), 8×His-Strep, Flag tagged

• Cat.No.: SLC19A1-1295H
• Product Overview: Recombinant Human 8His-Strep II-TEV-(GG)-SLC19A1 (V2-Q591)-Flag Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag&His&Strep
• Protein Length: V2-Q591
• Description: Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Formulation:
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: SLC19A1 solute carrier family 19 (folate transporter), member 1 [ Homo sapiens (human) ]
• Official Symbol: SLC19A1
• Synonyms: SLC19A1; solute carrier family 19 (folate transporter), member 1; folate transporter 1; FOLT; RFC; IFC-1; intestinal folate carrier 1; placental folate transporter; reduced folate carrier protein; solute carrier family 19 member 1; CHMD; IFC1; REFC; RFC1
• Gene ID: 6573
• mRNA Refseq: NM_001205206
• Protein Refseq: NP_001192135
• MIM: 600424
• UniProt ID: P41440