Recombinant Human Sirtuin 6, His-tagged

Cat.No. : SIRT6-357H
Product Overview : Recombinant Human SIRT6, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques, 41 kDa (375 aa).
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Species : Human
Source : E.coli
Tag : His
Description : The SIRT6 is included in class IV of the sirtuin family, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, in yeast sirtuins are known to regulate epigenetic gene silencing. Also SIRT6, a chromatin-associated protein, appears to be involved in DNA repair.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Purity : > 95% by SDS - PAGE.
Concentration : 1 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name SIRT6 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) [ Homo sapiens ]
Synonyms SIRT6; SIR2L6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6; sirtuin type 6; sir2-related protein type 6; EC 2.4.2.31; SIR2-like protein 6; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 6.
Gene ID 51548
mRNA Refseq NM_016539
Protein Refseq NP_057623
MIM 606211
UniProt ID Q8N6T7
Chromosome Location 19p13.3
Function NAD binding; NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding.

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