Recombinant Human SIRT6 Protein, His-tagged

• Cat.No.: SIRT6-24H
• Product Overview: Recombinant human SIRT6(1-355) protein with a N-terminal His-tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 43.7 kDa
• Protein length: 1-355
• Purity: ≥80% estimated by SDS-PAGE
• Stability: ≥ 6 months
• Storage: Store it at -80 centigrade
• Storage Buffer: 25 mM Tris-HCl, pH 8.0, with 100mM NaCl, 20% glycerol

Gene Information

• Gene Name: SIRT6 sirtuin 6 [ Homo sapiens (human) ]
• Official Symbol: SIRT6
• Synonyms: SIRT6; sirtuin 6; SIR2L6; NAD-dependent protein deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6
• Gene ID: 51548
• mRNA Refseq: NM_001193285
• Protein Refseq: NP_001180214
• MIM: 606211
• UniProt ID: Q8N6T7

Reviews

07/21/2022

This protein has high yield and good economic benefits.

05/25/2022

Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.

12/13/2021

SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

Q&As

How is SIRT6 involved in DNA repair?

SIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.

What is the nutritional significance of SIRT6?

This proteinexpression of genes related to fat metabolism through deacetylation modifications.

Does SIRT6 have therapeutic potential?

Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.

How does SIRT6 affect nutrient metabolism and energy balance?

SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.

What is the effect of loss of SIRT6 on cells?

Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.

How do the expression levels of SIRT6 differ in different tissues and cells?

There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.